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J Silvio Gutkind Selected Research

Small Interfering RNA (siRNA)

11/2023Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma.
1/2021Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer.
1/2020Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation.
6/2015Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.
2/2014Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models.
10/2012Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model.
7/2010PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
2/2009Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.
11/2007The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis.
6/2006Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.

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J Silvio Gutkind Research Topics

Disease

151Neoplasms (Cancer)
05/2024 - 01/2002
78Squamous Cell Carcinoma of Head and Neck
05/2024 - 06/2002
23Squamous Cell Carcinoma (Epidermoid Carcinoma)
10/2023 - 06/2003
23Carcinogenesis
12/2020 - 09/2002
20Neoplasm Metastasis (Metastasis)
09/2023 - 11/2004
18Head and Neck Neoplasms (Head and Neck Cancer)
10/2023 - 09/2007
15Carcinoma (Carcinomatosis)
01/2019 - 11/2002
12Uveal melanoma
11/2023 - 01/2013
10Breast Neoplasms (Breast Cancer)
06/2022 - 02/2005
9Mouth Neoplasms (Oral Cancer)
01/2021 - 11/2004
7Kaposi Sarcoma (Kaposi's Sarcoma)
01/2010 - 04/2004
6Lung Neoplasms (Lung Cancer)
05/2024 - 04/2005
6Lymphatic Metastasis
01/2016 - 03/2006
5Hyperplasia
01/2020 - 12/2004
5Melanoma (Melanoma, Malignant)
11/2019 - 01/2008
5Leukemia
11/2013 - 09/2002
4Colorectal Neoplasms (Colorectal Cancer)
01/2023 - 12/2002
4Wounds and Injuries (Trauma)
01/2019 - 06/2003
4Inflammation (Inflammations)
07/2013 - 02/2005
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2024 - 07/2012
3Prostatic Neoplasms (Prostate Cancer)
01/2020 - 11/2009
3Colonic Neoplasms (Colon Cancer)
06/2015 - 12/2005
3Hypoxia (Hypoxemia)
03/2009 - 02/2008
2Squamous Cell Neoplasms (Squamous Cell Cancer)
12/2022 - 01/2020
2Papillomavirus Infections
12/2022 - 05/2012
2Triple Negative Breast Neoplasms
06/2022 - 01/2016

Drug/Important Bio-Agent (IBA)

31Proteins (Proteins, Gene)FDA Link
05/2024 - 06/2002
23G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
05/2024 - 04/2004
20Sirolimus (Rapamycin)FDA Link
01/2019 - 11/2005
19Biomarkers (Surrogate Marker)IBA
10/2023 - 11/2002
16MTOR InhibitorsIBA
11/2022 - 12/2008
15GTP-Binding Proteins (G-Protein)IBA
01/2023 - 12/2005
12RNA (Ribonucleic Acid)IBA
01/2023 - 06/2002
11Immune Checkpoint InhibitorsIBA
12/2023 - 12/2017
10LigandsIBA
05/2024 - 09/2002
10Small Interfering RNA (siRNA)IBA
11/2023 - 06/2006
10Cisplatin (Platino)FDA LinkGeneric
01/2020 - 10/2003
9EnzymesIBA
05/2024 - 09/2006
9DNA (Deoxyribonucleic Acid)IBA
12/2021 - 11/2005
9TOR Serine-Threonine KinasesIBA
05/2013 - 11/2005
8Phosphotransferases (Kinase)IBA
11/2023 - 04/2003
8ErbB Receptors (EGF Receptor)IBA
02/2016 - 06/2003
7Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA
09/2023 - 09/2002
7CytokinesIBA
09/2023 - 06/2003
7Metformin (Glucophage)FDA LinkGeneric
01/2021 - 04/2012
7Epidermal Growth Factor (EGF)IBA
12/2010 - 05/2005
6Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA
12/2023 - 11/2007
6Rho Guanine Nucleotide Exchange FactorsIBA
01/2022 - 09/2002
6Protein Kinases (Protein Kinase)IBA
10/2021 - 04/2003
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021 - 11/2007
6Carbon Nanotubes (Carbon Nanotube)IBA
05/2014 - 02/2009
6beta CateninIBA
09/2009 - 08/2004
5ChemokinesIBA
09/2023 - 04/2006
5AntibodiesIBA
01/2022 - 06/2006
5Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
08/2021 - 01/2008
5Phosphatidylinositols (Phosphatidylinositol)IBA
01/2020 - 12/2005
5CarcinogensIBA
10/2016 - 08/2005
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
02/2015 - 11/2004
5Interleukin-6 (Interleukin 6)IBA
07/2012 - 06/2003
5Progesterone Receptors (Progesterone Receptor)IBA
05/2012 - 04/2011
5Transforming Growth Factor beta (TGF-beta)IBA
07/2009 - 08/2004
4EverolimusFDA Link
12/2022 - 11/2011
4Monomeric GTP-Binding ProteinsIBA
03/2013 - 11/2004
4ImmunosorbentsIBA
07/2012 - 11/2009
4Progestins (Progestagens)IBA
05/2012 - 04/2011
4Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2008 - 12/2002
3Neurotransmitter Agents (Neurotransmitter)IBA
05/2024 - 01/2020
3Chemokine ReceptorsIBA
05/2024 - 03/2015
3Focal Adhesion Protein-Tyrosine KinasesIBA
05/2024 - 10/2003
3tipifarnib (R115777)IBA
10/2023 - 01/2020
3Guanosine Triphosphate (GTP)IBA
01/2023 - 06/2007
3Estrogen Receptor alphaIBA
01/2022 - 01/2012
3Peptides (Polypeptides)IBA
01/2022 - 03/2007
3Protein Isoforms (Isoforms)IBA
10/2021 - 06/2015
3Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
10/2021 - 05/2011
3Transcription Factors (Transcription Factor)IBA
01/2021 - 03/2009
3Cetuximab (Erbitux)FDA Link
01/2020 - 09/2014
3Oncogene Proteins (Oncogene Protein)IBA
01/2020 - 03/2009
3AMP-Activated Protein KinasesIBA
01/2019 - 11/2008
3Retinaldehyde (Retinal)IBA
10/2016 - 05/2009
3Semaphorins (Semaphorin)IBA
07/2015 - 09/2002
3ParaffinIBA
10/2012 - 02/2008
3Heme Oxygenase-1IBA
10/2012 - 11/2007
3ProgesteroneFDA LinkGeneric
05/2012 - 04/2011
3Hormones (Hormone)IBA
08/2011 - 12/2002
3Complementary DNA (cDNA)IBA
03/2006 - 08/2004
2Cholinergic Agents (Cholinergics)IBA
05/2024 - 10/2023
2Serotonin (5 Hydroxytryptamine)IBA
05/2024 - 10/2023
2Adenosine (Adenocard)FDA LinkGeneric
05/2024 - 10/2023
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
11/2023 - 11/2005
2Farnesyltranstransferase (Farnesyltransferase)IBA
10/2023 - 01/2023
2InterferonsIBA
11/2022 - 12/2021

Therapy/Procedure

61Therapeutics
05/2024 - 10/2003
18Immunotherapy
12/2023 - 03/2006
9Drug Therapy (Chemotherapy)
01/2020 - 03/2006
6Radiotherapy
01/2020 - 01/2012
6Lasers (Laser)
05/2014 - 06/2003
4Transplantation
05/2024 - 08/2005
4Chemoprevention
10/2012 - 12/2006
3Precision Medicine
09/2022 - 01/2019